Abstract: In view of problems of no functions of real-time data display and processing, automatic closed-loop control and communication interface of current sensor calibration devices, the paper put forward a method of applying configuration software and Modbus communication agreement in mine-used gas sensor calibration device. The method can connect sensor calibration device with upper computer through a serial port and Modbus communication agreement and single-chip microcomputer, can control entire process of sensor calibration and dynamically collect and process data for each sensor. The practical application showed that the method can realize automation, precision of mine-used gas sensor calibration device, which guarantees safety production of coal mine.