Abstract: In order to reveal dynamic appearance regularity of blow-out from drilling hole in deep low gas coal seam of Panxi Coal Mine, field tests of gas content and mining stress were carried out in 6198 working face of Panxi Coal Mine, and simulation analysis of stress distribution in front of 6198 working face was also done by use of FLAC3D software. Distribution regularities of gas content and stress in the working face were studied, and dynamic appearance mechanism of blow-out from drilling hole in low gas coal seam was analyzed. The study results show that gas content in 6198 working face is low in general, and the greater mining depth is, the higher gas content is. Affected by faults, the maximum stress concentration factor in front of the working face is 1.36. Dynamic appearance of blow-out from drilling hole in low gas coal seam in 6198 working face of Panxi Coal Mine is a process of coal body crushing under high stress and then spraying under gas pressure. Internal potential released by coal body and gas internal energy can provide energy for coal body to break and move. Compared with shallow coal seam, threshold of gas expansion energy decreases which causes dynamic appearance of blow-out from drilling hole in deep low gas coal seam.