In view of problems that intelligent sensors in safety monitoring and control system of coal mine need make field setting and periodic calibration for parameters, the paper proposed a design scheme of intelligent setting device taking P89LPC936 single-chip microcomputer as core. The setting device communicates with intelligent sensors through RS232 serial port and can accurately receive and display measured values and other parameters of all kinds of intelligent sensors; it makes real-time and field setting and calibration for parameters such as upper limit and lower limit of measurement and address of intelligent sensors through RS232 serial port; it can accurately measure and display bus current and supply current of intelligent sensors so as to judge working state of intelligent sensors. The actual application showed that the setting device has characteristics of convenient in carrying, simple in operation, stable and reliable in running.