Abstract: The paper analyzed structure design of transportation signal system for mine rubber-tyred locomotive and pointed out that distributed structure should be used for higher reliability and real-time performance. It introduced structure of distributed control system and proposed taking CAN bus as main transmission method after comparing RS485 with CAN bus. It also introduced the distributed structure and working flow of transportation signal system for mine rubber-tyred locomotive. The application showed that the transportation signal system for mine rubber-tyred locomotive based on distributed structure has higher reliability and real-time performance than the system based on traditional master-slave structure.