Abstract: In allusion to problems that coal mine gas sensor uses manual calibration may lead to toxic gas threat to personnel life, the paper proposed a design scheme of transmit module of infrared signal, and introduced infrared adjustment principle, obtain of transmission protocol for infrared signal, hardware and software designs of the module and its application in sensor calibration. Integrating the module to calibration equipment can achieve automatic closed-loop calibration of sensor, while a wide range of infrared signal transmission protocols can be integrated in database of host computer system, which enables users to complete setting of technical parameters of sensors by simply selecting the corresponding type of sensor, so as to improve work efficiency.