Abstract: In view of problem that disaster early-warning rescue system and environment prediction system have limitations because of independent running of the both, the paper proposed a design scheme of integrated system of disaster early-warning rescue and environment prediction of mine. It gave design idea and framework of the system and expounded design principle of four interdependent subsystems of data collection, disaster early-warning, rescue and command and environment prediction, and introduced structure and design principle of man-machine interface of the system. The research of the system has significance for underground rescue work.