Abstract: The paper analyzed interference inducing model, pointed out that common interference sources are radiation interference, conducted interference and construction interference in industrial automatic control system, and analyzed generating principle of above interferences. Then it advanced to adopt anti-interference measures in terms of field construction and design methods including power source design, grounding system design, pipeline design, component selection and software design, and gave common anti-interference measures. Finally it took a control system of gas station for example to introduce application scheme of anti-interference measures in actual industrial field, which verified that appropriate anti-interference measures can decrease interference effectively and improve reliability of industrial automatic control system.