Abstract: Taking the design of monitoring and control system of compressor house of north ventilation shaft in No.8 Coal Mine of Pingdingshan Tia'an Mining Co., Ltd. as an example, the paper introduced characteristics and parameters of TPC1063E touch screen and MCGS configuration software, and gave general steps of configuration of the touch screen. It also gave implementation of project analysis, engineering framework, data object, graphic making, flow control, program debugging, driver programm of connection device and integration testing according to concrete conditions. The practical application showed that the touch screen works well and has easy operation because of friendly interface, which provides a guarantee for safe equiblast underground.