Abstract: To solve problems of long time of network training,easy to fall into local minimum and easy to early maturity existed in traditional method of impulsion pressure prediction,the paper proposed a method using CLGA to predict impulsion pressure.It introduced basic steps using CLGA to optimize weight and threshold of BP neural network in details and made simulation experiment using Matlab7.1 to build network model on PC.The simulation result showed that the method can improve accuracy of impulsion pressure prediction effectively.