Abstract: In order to solve problems of inconvenience and complexity of eccentric injection of oilfields,a design scheme of intelligent measuring and adjusting system for zonal injection flow based on PIC16F877A was proposed and working principle and design of software and hardware of the system were introduced. Fuzzy control method is used in the system to adjust and control injection flow intelligently and serial port is used to realize communication between upper and lower computers. The system has functions of automatic adjustment of each zonal injection flow and remote monitoring. The test result showed the system has stable running, quick respond speed of flow adjustment, high precision and small error of adjustment with high reliability and anti-interference ability.