Abstract: Taking PJR-2X concrete spraying robot as example, the paper introduced a design method of human-machine interactive 3D simulation platform based on MFC of VC++ and OpenGL. The method uses Solidworks software to build model of the robot, storages 3D model as .STL file which is introduced into 3DSMax to establish texture coordinates, and output 3DS file is introduced into Deep Exploration to make secondary processing of material and texture of 3D model. Finally, the file is introduced into working scene which is built by OpenGL to make scene rending through MFC, so as to get lively 3D virtual simulation platform of the robot. The actual application showed that the simulation platform can express characteristics of observe and inverse motion of the robot accurately and can make demonstration.