Abstract: The self-adaptation detection system of strain adopted a design technology that can adjust balance of input bridge automatically,which used ARMS3C4510B to adjust digital potentiometer, so as to realize self-adaptation zeroing and improve detection precision. In addition, according to the value of input signal, this system could adjust amplification of amplifier adaptively so that the different amplification was adopted for input signal in different range, which could ensure the signal value was in 1/2~1 full range.