Abstract: In view of actuator saturation problem in switchover process of mine ventiliator, an adaptive PID anti-saturation controller was designed based on combination of variable structure PID anti-saturation control and nonlinear adaptive control. Based on the projection algorithm of dead zone, the linear and nonlinear models of switchover process of mine ventilator were established. A variable structure PID anti-saturation controller was designed respectively for the two models. The operation evaluation indexes of linear and nonlinear adaptive PID anti-saturation controller in different states were calculated, and the controller with smaller evaluation index value was selected for the switchover process control of mine ventilator in this state. The simulation results show that the adaptive PID anti-saturation controller can ensure smooth transmission of underground air volume and solve the problem of actuator saturation.