Abstract: In order to master development and evolution law of cable fire in coal mine chamber, FDS software was used to simulate smoke flow, carbon monoxide concentration, oxygen concentration and temperature during development process of cable fire in coal mine chamber. The results show that: ① With increase of time of cable fire in coal mine chamber, smoke flow will accelerate to spread the whole chamber; carbon monoxide concentration increases firstly, then decreases and finally tends to be stable; oxygen concentration decreases firstly, then increases and finally tends to be stable; temperature increases firstly, then decreases and finally approaches initial temperature. ② Concentration of carbon monoxide and oxygen in return airway fluctuates violently, and temperature fluctuation is relatively small, while carbon monoxide concentration, oxygen concentration and temperature in air inlet roadway are not affected by fire, so the air inlet roadway can be used as a safe escape route. ③ Within 60 s after the fire occurs, smoke flow has a small spreading range and concentrates in middle-upper part of chamber, and carbon monoxide concentration, oxygen concentration and temperature are all within safe range. The best time to escape is within 60 s after the fire occurs.