Abstract: In view of problems of high gas pressure and poor permeability of outburst coal seam, unsatisfactory of outburst elimination effect of regional gas control, slow speed of coal roadway excavation and tension of working face replacement caused by deep mining on 15-17220 working face in the Twelfth Coal Mine of Pingdingshan Tia'an Coal Mining Co., Ltd., a regional gas control scheme of "crossing boreholes + hydraulic punching" was proposed, and the regional gas control effect was tested and verified. The following conclusions are obtained: residual gas content and pressure are reduced to 5.57 m3/t and 0.40 MPa, they are lower than threshold of outburst prevention regulation, which achieve outburst prevention standard for coal mine safety mining; drilling cuttings and borehole gas emission initial velocity respectively are reduced to 3.5 kg/m and 2.18 L/min, the indicators are not overweight, so as to eliminate outburst danger of coal seam; coal roadway excavation footage is risen every month steady with 10%, and effectively relieves problem of tension of working face replacement. The control results validate rationality of the regional gas control scheme.