Abstract: A design scheme of physiological data acquisition and processing system for underground personnel was proposed. Hardware design of data acquisition terminal, data acquisition and processing method and ZigBee data transmission design of the system were introduced. The system can acquire the data of oxygen saturation of blood, pulse and body motion of underground personnel real-timely, and get physiological condition of the personnel by processing the acquired data, which displays on monitoring interface of upper computer. The test results show that the accuracy of data acquisition of the system is over 90%, and data transmission is reliable without data packet loss.