Abstract: In view of problem of poor anti-interference capability of existing coal mine safety monitoring system and composition equipment, and requirements of "strengthening the anti-electromagnetic interference ability of the system and the equipments" of the National Coal Mine Safety Supervision Bureau on the upgrading of coal mine safety monitoring system, the paper expounded how to improve anti- interference capability of current safety monitoring system and composition equipment from aspects of mechanical structure design, hardware circuit design and software design. The practical application results show that the device applying the described anti-interference designs can pass three-stage electrostatic discharge immunity test, two-stage radio frequency electromagnetic radiation immunity test and other test items.