Abstract: The three-dimensional structure model of unilateral driven swing screen was established by PROE software, and the load history on the eccentric shaft was obtained by dynamic simulation analysis. The stress distribution curve and stress cloud of the eccentric shaft were analyzed by using analytical method and finite element method. The analysis results show that the dangerous part of the eccentric shaft appears at the support of the intermediate bearing, and the maximum stress is about 35 MPa. The fatigue life (0.98 a) of the eccentric shaft was calculated by using the local stress-strain method, which can effectively prevent accident occurrence. These results provide a reliable basis for design and improvement of eccentric shafts.