Abstract: The paper analyzed current situation of application of existing mine ventilation system, pointed out the shortages of the current ventilation system. It gave research method of intelligent ventilation system on the basis of industrial 4.0 concept, and proposed design scheme of an intelligent ventilation system based on field bus technology according to the research method. The system adopts modular design method to design several independent modules, such as data collection, analysis and processing, decision-making execution subsystem, uses Ethernet technology to transmit data, and uses the CAN bus network to realize control function, which can realize air supply according to demand and adjustable air volume in advance.