Abstract: For low real-time performance of traditional serial data processing mode, a design scheme of multi-protocol gateway based on FPGA was proposed, and the overall architecture, key hardware circuit design and software design were given. The gateway takes advantage of parallel execution of FPGA, and can access 485 bus signal, CAN bus signal, frequency signal, digital signal, ZigBee wireless signal and Ethernet signal. It achieves simultaneous acquisition and real-time transmission of sensor signals with different rates and interfaces.