Abstract: In view of problems of complex wiring and high damage rate of communication cable existed in cable communication mode between PLC centralized control system of coal preparation plant and field equipment, a design scheme of PLC centralized control system of coal preparation plant based on wireless communication was proposed. The system uses CP340 communication module and data radio station to realize wireless communication between lower computer control station S7-300 PLC and ET200M distributed I/O substation, solves problems of complex cable wiring, high cable damage rate and inconvenient maintenance of coal preparation plant communication, and realizes data wireless communication of centralized control system of coal preparation plant.