Abstract: In view of the problem of centrifugal pump impeller wear, the existing research mostly concentrates on numerical simulation analysis, vibration signal analysis and wear detection of impeller wear. There are few studies on the working condition parameters of centrifugal pump under impeller wear. In order to solve this problem, a health condition assessment method of centrifugal pump based on analytic hierarchy process (AHP) and technique for order preference by similarity to ideal solution (TOPSIS) is proposed. Firstly, according to the operating conditions of centrifugal pump and the performance requirements of centrifugal pump, the operating parameters (flow, head, efficiency and shaft power) characterizing the health condition of centrifugal pump are determined. Secondly, the outer diameter and the specific speed of the impeller are taken as the evaluation indexes of the working condition parameters. The weight values of each working condition parameter to the health condition of the centrifugal pump are determined by using the AHP and the super-transitive approximate method. Finally, the working condition parameters of the centrifugal pump are evaluated by TOPSIS comprehensive evaluation method. The health condition score of the centrifugal pump is obtained by weighted summation, to realize the health condition evaluation of the centrifugal pump. Taking the IS-100-80-125 single-stage centrifugal pump as the research object, the outer diameter of the impeller is worn from 125 mm to 87 mm, and the working parameters of the centrifugal pump with different outer diameters of the impeller are obtained. The working parameters and the health condition of the centrifugal pump are evaluated by the AHP-TOPSIS comprehensive evaluation method. The results show that there is a linear relationship between impeller wear and centrifugal pump health. With the increasing wear of impeller, the drainage capacity of centrifugal pump decreases. The evaluation results are in line with the actual situation of the centrifugal pump, which proves the rationality and feasibility of this method.