Abstract: For existing status of low emergency decision-making and intelligent control level and inability to remotely control wind-smoke flow under abnormal conditions of mine ventilation, a regional linkage and intelligent control system of mine fire wind-smoke flow was designed. Combining with ventilation network structure, regional linkage control mechanism of wind-smoke flow during fire period was analyzed, which realized wind volume distribution according to needs of two parallel branches of smoke flowing zone and non-smoke flowing zone during fire period through setting smoke sensor, adjustable air doors and other ventilation equipments and remote control. Influence factors on intelligent control of mine fire wind-smoke flow were researched. An intelligent control model of wind-smoke flow during fire period was built through analyzing ventilation network structure before and after mine fire, and realization algorithm of visual function was also introduced. The system obtains real-time wind volume of each branch according to wind resistance, ventilation network structure and operation parameters of main ventilator during fire period, calculates ideal wind volume of key roadways through simulating fire process and sets a threshold value. When error between actual wind volume and the threshold value exceeds 10%, open degree of air door is controlled remotely, so as to realize optimal wind distribution. The application result shows that there is a perfect coupling among simulated calculation result of the system, displaying result on visual interface and field test result of wind volume in roadway.