Abstract: In view of problems that there was no standard for security management and supervision method was backward in terms of safety control, occupational health and environmental protection in current enterprises, construction plan of enterprise health, safety and environment (HSE) control platform based on public clouds was proposed. Physical architecture and functional architecture design of the platform were introduced, and key points, key technologies of platform construction and platform advantages were analyzed. Planning, execution, inspection, and action (PDCA) management and control system are used to combine real-time dynamic monitoring with daily static business management, event/accident drive is applied to achieve rapid response, and emergency management and emergency response are adopted to achieve auxiliary emergency rescue under catastrophic conditions. Continuous optimization of HSE overall dynamic assessment and control indicators and implementation process is achieved by convergence of indicator plan, implementation efficiency, control effects, and other factors, then strength and depth of management and control are improved. The platform fully utilizes technical advantages and operation and maintenance modes of cloud computing and the Internet of things, reduces construction cost and operation and maintenance difficulty of the HSE project, and improves regulatory efficiency and supervision depth.