Abstract: Design of wireless communication system of an open-pit mine was analyzed. Principle and technical characteristics of three kinds of networking modes were introduced and compared including radio modem, Mesh and GPRS. Mesh networking mode was determined as the wireless communication system solution. Composition structure, network design and base station establishment of wireless Mesh network were expounded. The application shows that the wireless communication system realizes full cover of wireless network in the open-pit mine and improves real-time and reliability performance of information transmission.