Abstract: For problems of premature convergence and easily fall into local optimal solution existed in inversion method of calculation parameters of mining subsidence, ant colony algorithm was applied to calculation parameters inversion of mining subsidence. Firstly, search space of inversion parameter is discretized, thus parameter inversion problem is transformed into combination optimization problem, and then flow of calculation parameters inversion of probability integral method based on max-min ant colony algorithm is established. Application results show that the ant colony algorithm has strong anti-interference ability for missing data of measuring points, which has better fitting effect than least square method and pattern search method.