Abstract: Traditional hole-sealing materials have some disadvantages such as long concretion time, poor airtightness caused by shrinkage and xerochasy and so on under the condition that drilling hole of water-bearing coal seam passes fissure zone. A new type of hole-sealing reagent was proposed on the basis of traditional grout and applied in high pressure grouting hole-sealing process in a coal mine. Application result shows that concretion time of the new hole-sealing reagent is 12 h, and the new hole-sealing reagent has more reliable measurement result of gas pressure of coal seam than traditional hole-sealing material as well as better effect of water stem.