In order to solve problems that safety instruments for mine ventilation are easily drawn on by error, missed and recorded inaccurately caused by manual dispensation, withdrawal and record with forms at present, the paper put forward a design scheme of computer management system of safety instruments for ventilation. The system uses technologies of automatic recognition of barcode and computer network to realize computer management of safety instruments for mine ventilation. The actual running showed that the system is stable in operation, reliable in performance and correct in data.