Due to the difference between fully-mechanized caving face and single stoping process face, there would be a big error in predicting gas emission rate on fully mechanized caving face by use of AQ 1018-2006 The Predicted Method of Mine Gas Emission Rate. Meanwhile, there is a lack of research on prediction of gas emission rate on fully-mechanized caving face with layered mining of thick coal seam at present, which results in weak technology base for gas control. For the above problems, a prediction method of gas emission rate on fully-mechanized caving face with layered mining of thick coal seam was proposed. By analyzing gas emission characteristics of the fully-mechanized caving face, gas emission sources were determined including gas from coal cutting, coal caving, goaf and adjacent layers. Corresponding calculation formulas of gas emission rate were obtained according to different gas emission sources, so as to get a calculation formula of gas emission rate on fully-mechanized coal-caving face with layered mining of thick coal seam. The method has been used to predict gas emission rate on fully-mechanized caving faces of Wudong Coal Mine and Jia'gou Coal Mine separately, and the results show that the error between the predicted result and the measured value is less than 5% to meet actual production needs.