Abstract: In view of requirements for characteristics of mine management system such as precision mining, heterogeneity, distribution, autonomy and data driving, a mine distributed hierarchical autonomous system based on mine cyber-physical system was proposed. The system is composed of wisdom sensing and control layer, information transmission layer, unified scheduling layer, model description layer and control and application layer. Sensing and control nodes of the wisdom sensing and control layer can realize ubiquitous perception, control and adjustment for human, machine and environment. The information transmission layer not only combines backbone network and sub-network, but also combines wired network and wireless network, so as to improve reliability of data transmission and reduce generation of information isolated islands. The unified scheduling layer can realize unification of system semantics and system time, which improves efficiency of data utilization. The model description layer can realize digital description of overall mine. The control and application layer is accessed to mine application system, which can reduce development difficulty of the mining application system and improve wisdom of mine management. The system has reliability, cooperativity and autonomy, and provides technical support for mine precise mining, unattended work and few people operation.