Abstract: For problems of larger error of coal mine ventilation resistance measurement data acquired by barometer base-point method and cumbersome correction of existing original measurement data processing methods, a data processing method of coal mine ventilation resistance measurement based on relative pressure was proposed. In the method, a pithead inlet of coal mine is selected as zero point of relative pressure firstly. Then relative pressures of other measurement points are calculated, and relative pressures of some measurement points that do not conform to sequencing principle are corrected. Finally, wind resistances of all tunnels are calculated according to ventilation resistance law, and according to comparison result between calculated wind volume and the measured reliable one of the same tunnel, wind resistances of some tunnels are corrected whose comparison errors are over 5% until the comparison errors of wind volume in all tunnels are within 5%. The method can complete initial error correction of original measurement data at one time, improve efficiency of obtaining reliable basic ventilation parameters, and has a certain reference value for data processing of coal mine ventilation resistance measurement.