Abstract: In view of problems of very limited function of LoWPAN_HC1 and LoWPAN_HC2 for global address and multicast address, and nondirectional broadcast communication and redundant network communication consumption of LoWPAN_IPHC in header compression technology of 6LoWPAN of Internet of Things, the paper proposed a header compression method of 6LoWPAN of Internet of Things based on cluster strategy, namely LoWPAN_CIPHC. The method uses cluster strategy to refine destination address and source address of header compression, which not only can make the best communication path of internal network, but also control broadcast area easily. The test result showed that LoWPAN_CIPHC can reduce network communication consumption without adding calculation comparing with LoWPAN_IPHC.